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Dickey’s lab started finding out mucin secretion two decades ago and previously identified the key genes and proteins involved, showing how synaptotagmin and a SNARE complicated, comparable to that located in neurons, lead to The crucial element strategy of Ca2+-brought on membrane fusion.
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As a result, blocking the action of Syt2 really should reduce unexpected large mucin launch without having impairing sluggish, constant baseline mucin secretion that is necessary for airway health.”
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